Title
Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
Authors
Krishnamoorthy Meenakumari & Giridharan Bupesh*
Affiliation
Research and Development Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital (SBMCH), BIHER, Chrompet, Chennai - 600044, India
Dr. Giridharan Bupesh, - Phone: +91 8012405965, Email: bupeshgiri55@gmail.com.
Article Type
Research Article
Date
Received January 3, 2020; Revised April 30, 2020; Accepted May 8, 2020; Published June 30, 2020
Abstract
It is of interest to document the molecular docking of C-Jun-N-Terminal Kinase (Jnk) (known structure with PDB ID: 1PMN) with aminopyrimidine derivatives in the context of Alzheimer’s Disease (AD). We report the optimal binding features (binding energy, interacting residues, inter atomic hydrogen bonding patterns) of 11 amino-pyrimidine derivatives with Jnk for further consideration.
Keywords
JNK3, inhibitors, amino-pyrimidine
Citation
Meenakumari & Bupesh, Bioinformation 16(6): 462-467 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
