Title

Molecular docking analysis of N-substituted oseltamivir derivatives with the SARS-Cov-2 main protease

Authors

Assia Belhassan¹, Samir Chtita², Hanane Zaki¹, Tahar Lakhlifi¹ and Mohammed Bouachrine^1,3*

Affiliation

¹Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, Moulay Ismail University of Meknes, Morocco; ²Laboratory of physical chemistry and materials, Faculty of science Ben M’Sik, Hassan II University of Casablanca, Casablanca, Morocco; ³EST Khenifra, Sultan Moulay Sliman University,

Email

Benimellal, Morocco; *Corresponding Author: E-mail: m.bouachrine@est-umi.ac.ma &
bouachrine@gmail.com

Article Type

Research Article

Date

Received April 6, 2020; Revised April 22, 2020; Accepted April 22, 2020; Published May 31, 2020

The identification of chemotherapeutic drugs against Novel Coronavirus (2019-nCoV) is a significant requirement due to the rapid rise in deaths due to Corona Viral Infection all around the world. Therefore, it is of interest to document the molecular docking analysis data of 32 N-substituted Oseltamivir derivatives inhibitors of influenza virus H5N1 with the Novel Coronavirus main protease (2019-nCoV). We describe the optimal binding features of Oseltamivir derivatives with the SARS-Cov-2 main protease (Code PDB: 6LU7) for further consideration.

Keywords

Coronavirus, COVID-19, SARS-CoV-2, oseltamivir, H5N1, molecular docking

Citation

Belhassan et al. Bioinformation 16(5): 404-410 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.