Title

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer

Authors

Rajagopal Ponnulakshmi¹, Veeraraghavan Vishnupriya², Surapaneni Krishna Mohan³, Srinivasan
Abilasha⁴, Govindan Ramajayam⁵, Periyasamy Vijayalakshmi⁶, Manikkam Rajalakshmi⁶, Jayaraman Selvaraj²*

Affiliation

¹Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; ²Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ³Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Chennai, Tamil Nadu, India ⁴Department of Anatomy, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu, Tamil Nadu, India; ⁵Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India; ⁶DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamil Nadu, India;

Email

Dr. Jayaraman Selvaraj - E-mail: jselvaendo@gmail.com; *Corresponding author:

Article Type

Research Article

Date

Received February 15, 2019; Revised March 10, 2020, Accepted March 18, 2020; Published March 31, 2020

It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.

Keywords

Colon cancer, β-catenin, Molecular docking, ADME

Citation

Ponnulakshmi et al. 16(3): 283-287 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.