Title

Molecular docking analysis of zanamavir with haemagglutinin neuraminidase of parainfluenza virus type 3

Authors

C. P. Indumathi^1*, G. Bupesh^1,2*, S. Vasanth², V. Senthilkumar¹, A. Vijaya Anandh⁴,
K. Pandian3

Affiliation

¹Department of Virology, King Institute of Preventive Medicine and Research, Guindy, Chennai, India; ²Research & Development Wing, Sree Balaji Medical College & Hospital, BIHER, Chrompet, Chennai-600044, India; ³Department of Inorganic Chemistry, University of Madras, Guindy, Chennai-600032, India

Email

Dr. G. Bupesh - Phone:+91 8012405965; Email: bupeshgiri55@gmail.com; Dr. C. P. Indumathi - Email: ammindhu@gmail.com; *Corresponding authors

Article Type

Research Article

Date

Received September 28, 2019; Revised October 30, 2019; Accepted October 30, 2019; Published October 31, 2019

The human para influenza virus (HPIV) type 3 is an imperative respiratory virus which cause upper and lower respiratory infections. The receptor involved in the viral infection is haem agglutinin neuraminidase. It is of interest to study the interaction of haem agglutinin neuraminidase with zanamavir (4-GU-DANA), a known antiviral drug. We used the PDB structures with PDB IDs 1V2I, 1V3B, 1V3D and 1V3E for studying the interactions with zanamavir. The binding features of zanamavir with 1V2I (1.41kcal/mol) and 1V3E (11.81kcal/mol) having optimal interactions is reported for further consideration.

Keywords

Human para influenza virus, respiratory infections, haem agglutinin, neuraminidase, molecular docking

Citation

Indumathi et al. Bioinformation 15(10): 730-734 (2019)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.