Title

The combined effect of Trigonella foenum seeds and Coriandrum sativum leaf extracts in alloxan induced diabetes mellitus wister albino rats

Authors

TY Sree Sudha^1,*, Raghupathi Niranjan Kumar, Chakali Ayyanna, X Yakaiah, Anjaly Mary Varghese, X Amaravathi

Affiliation

¹Department of Pharmacology, AIIMS Medical Institute, Raipur, Chhattisgarh, India, 492099; ²Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal, Andhra Pradesh, India, 518502; ³Department of Pharmacology, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India, 518501; ⁴Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India, 518001; ⁵Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal, Andhra Pradesh, India, 518502; ⁶Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal, Andhra Pradesh, India, 518502; ⁷Department of Pharmacology, SVS Medical College and General Hospital, Mahabubnagar, Andhra Pradesh, India, 509001.

Email

Sree Sudha TY - E-mail: sudhambbs2010@gmail.com; *Corresponding author

Article Type

Research Article

Date

Received September 30, 2019; Revised October 19, 2019; Accepted October 20, 2019; Published October 22, 2019

Diabetes mellitus is a group of heterogeneous disorders commonly presenting with episodes of hyperglycemia and glucose intolerance, as a result of lack of insulin, ineffective insulin action, and/or both. It is our interest to study the effect of ethanolic extract of Trigonella foenum seeds (fenugreek) and Coriandrum sativum leaves (dhaniya) or its combination in alloxan induced diabetes mellitus wister albino rats. Rats were randomly separated into six groups where group 1 animals received 2% acacia, group 2 animals received alloxan dose of 150 mg/kg, group 3 animals received glibenclamide dose of 0.5 mg/kg and group 4, 5 & 6 animals received ethanolic extracts of Trigonella foenum seeds, Coriandrum sativum leaves and combination of both extracts at the dose of 100mg/kg for 21 days. Different biochemical parameters such as hepatic & renal biomarkers and histopathology of pancreas were studied. Combination of both extracts showed significant decrease in blood glucose, cholesterol, triglycerides, LDL, VLDL levels, SGOT, SGPT, urea, creatinine and increase in HDL levels and body weight than individual extracts. Thus, we show the antidiabetic activity of poly herbal formulation using biochemical and histo pathological data.

Keywords

PI3-kinase, screening, docking studies, MM-GBSA

Citation

Sree Sudha et al. Bioinformation 15(10): 716-722 (2019)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.