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Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats


1Vangoori Yakaiah*, 2Anusha Dakshinamoorthi*, 3Subramanian Kavimani



1Santhiram Medical College, Nandyal (AP). (PhD)-SRIHER, Chennai; 2Sri Ramachandra Institute of Higher Education and Research. Chennai; 3Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry.



Anusha Dakshinamoorthi -, *Corresponding author:


Article Type

Research Article



Received September 30, 2019; Revised October 7, 2019; Accepted October 9, 2019; Published October 13, 2019



It is of interest to evaluate the effect of Myristica fragrans on body composition of cafeteria diet induced obese rats. Thirty rats (150-160g) grouped into 5 and each group contains 6 rats. Group-1 was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity. From 16th week to 25th week test drugs were given as mentioned in the experimental protocol. Body weight, BMI, changes in body composition was measured by TOBEC, adipose tissue weights, organ weights, abdominal circumference were measured according to standard methods. After 70days of treatment with MFE 200mg/kg, 400mg/kg Body weight reduced by 9.29%, 12.87% respectively. BMI was also decreased. Abdominal circumference, total fat percentage, organ weights, was substantially reduced. At 400mg/kg of MFE has shown maximum potentiality when compared with 200mg/kg. Orlistat 50mg was used as standard drug. Tetrahydrofuran, flavonoids,
saponins, present in Myristica fragrans has shown anti obesity activity. Our findings explain the potentiality of phytochemicals as a potent anti obesity agent, provide scientific evidence for its traditional use and suggest the possible mechanism of action.



Obesity, BMI, abdominal circumference, total fat, adiposity index, tetra hydrofuran.



Yakaiah et al. Bioinformation 15(9): 657-665 (2019)


Edited by

P Kangueane






Biomedical Informatics


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