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Title

Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis

 

Authors

Shouhartha Choudhury

 

Affiliation

Department of Biotechnology, Assam University, Silchar-788011, Assam, India

 

Email

Email: shouharthac@gmail.com; Phone: +91-9365860541

 

Article Type

Research Article

 

Date

Received December 12, 2018; Accepted January 7, 2019; Published June 15, 2019

 

Abstract

The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervous system. These oligo-dendrocyte lineage genes OLIG1 and OLIG2 encode basic helix-loop-helix transcription factors. The murine bHLH transcription factors found in chromosome 21 are essential for oligo-dendrocyte development. Moreover, OLIG3 of the OLIG family is known to be linked with the brain and spinal cord development. Therefore, it is of interest to analyse oligodendrocyte lineage genes in the OLIG family of bHLH domain for the understanding of oligo-dendrogenesis in eukaryotes. We report several bHLH domain linked basic-helix-loop-helix transcription factors in Homo sapiens and Mus musculus from this analysis. Thus, genomics data analysis of OLIG family of bHLH transcription factors help explain observed similarity and differences within the molecular evolutionary context and hence assess the functional significance of the distinct genetic blueprints.

 

Keywords

OLIG family; bHLH transcription factor; oligo dendrogenesis

 

Citation

Choudhury, Bioinformation 15(6): 430-438 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.