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Title

Annotation of a hypothetical protein (WP_002969292.1) from Brucella abortus

Authors

Kanchan Rauthan1$, Divya Goel1$, Sudhir Kumar1*

 

Affiliation

1Department of Biotechnology, Hemvati Nandan Garhwal University, Srinagar Garhwal, Uttarakhand-246174, India

 

Email

sudhir.1685@gmail.com; *Corresponding author

 

Article Type

Research Article

 

Date

Received April 1, 2019; Accepted April 17, 2019; Published April 30, 2019

 

Abstract

Brucellosis is a zoonotic disease caused mainly by the bacteria belonging to the genus Brucella, most common of them is Brucella abortus. Genome sequencing of Brucella was completed in 2005. While majority of the proteins were assigned function, a large number of the peptides remained un-annotated and were referred as 'hypothetical'. These hypothetical proteins may contain crucial information about the biology and pathogenesis of the B. abortus. Therefore, it is of interest to annotate one such hypothetical protein as a multiple antibiotic resistance regulator protein, MarR. The physiological parameters, localization and the structural features were predicted for this protein which corroborated as the winged-helix type DNA-binding domain superfamily of transcription factors.

 

Keywords

Annotation,  hypothetical protein, Brucella abortus

 

Citation

Rauthan et al. Bioinformation 15(5): 315-320 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.