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Title

Molecular docking analysis of netropsin and novobiocin with the viral protein targets HABD, MTD and RCD

 

Authors

Afaf S. Alwabli#, Sana G. Alattas, Alawiah M. Alhebshi, Nidal M. Zabermawi, Naser Alkenani,
Khalid Al-ghmady, Ishtiaq Qadri

 

Affiliation

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia

 

Email

Afaf S. Alwabli - Email 1: afafalwabli@yahoo.com; Email 2: aalwabili@stu.kau.edu.sa, Phone: +966531937700; #Corresponding Author

 

Article Type

Research Article

 

Date

Received February 17, 2019; Revised March 3, 2019; Accepted March 9, 2019; Published March 30, 2019

 

Abstract

Dengue, West Nile and Zika virus belongs to the family flaviviridae and genus flavivirus. It is of interest to design and develop inhibitors with improved activity against these diseases. We used the helicases target to screen for potential inhibitors against these viruses using molecular docking analysis. NS3 helicases of flavivirus family of viruses such as Dengue, West Nile and Zika are prime targets for drug development. The computer aided molecular docking analysis of netropsin and novobiocin with the viral protein targets HABD, MTD and RCD is reported for further consideration.

 

Keywords

Dengue, therapeutics, helicase ATP binding domain, methyl transferase and RNA catalytic domain.

 

Citation

Alwabli et al. Bioinformation 15(4): 233-239 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.