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Insights from the molecular docking analysis of phytohormone reveal brassinolide interaction with
HSC70 from Pennisetum glaucum



Baloji Gugulothu1, Shobharani Pasham1, Vinodha Mahankali1, Mallikarjuna Garladinne2, Srinivas



1Department of Genetics & Biotechnology, Osmania University, Hyderabad (T.S) - 500 007, India; 2Plant Molecular Biology Laboratory, Agri Biotech Foundation, Rajendra Nagar, Hyderabad (T.S) 500 030, India



Srinivas Ankanagari E-mail:; *Corresponding author


Article Type

Research Article



Received January 14, 2019; Revised February 1, 2019; Accepted February 1, 2019; Published February 28, 2019



The prevailing abiotic stresses, especially heat stress is of great significance on the growth of plants, yield and distribution. In the conditions of heat stress, plants modulate protein processes leading to development of heat tolerance. Of such proteins, the molecular chaperone functions of HSP70/HSC70 proteins are important where their enhanced expression positively correlates with the acquisition of heat tolerance. The key players in the regulation of such tailored protein responses of plants to heat stress are the phytohormones. In the present study, phytohormone mediated interaction of Pennisetum glaucum HSC70 (PgHSC70) protein was performed through docking
studies involving sequence analysis, 3D modeling and model evaluation. In silico analysis has shown better interaction and good binding energy of PgHSC70 with the phytohormone brassinolide. Furthermore, the predicted structural information can be helpful for future studies on role of interaction between HSC70 and brassinolide in heat tolerance.



heat stress, HSP70/HSC70, phytohormones, heat tolerance



Gugulothu et al. Bioinformation 15(2): 131-138 (2019)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.