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Title

Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis

Authors

Housna Arrouchi1*, Wiame Lakhlili1 & Azeddine Ibrahimi1

 

Affiliation

1Biotechnology Laboratory (Medbiotech), BioInova Research center, Rabat Medical and Pharmacy School, Mohammed V University in Rabat, Rabat, Morroco;

 

Email

Housna Arrouchi - E-mail: Housna.arrouchi@um5s.net.ma; *Corresponding Author

 

Article Type

Research Article

 

Date

Received January 19, 2019; Revised February 1, 2019; Accepted February 1, 2019; Published February 28, 2019

 

Abstract

The Concept of reusing existing drugs for new targets is gaining momentum in recent years because of cost-effectiveness as safety and toxicology data are already available. Therefore, it is of interest to re-profile known drugs against the Pim-1 kinase target using molecular docking analysis. Results show that known drugs such as nilotinib, vemurafenib, Idelalisib, and other small kinases inhibitors have high binding ability with Pim-1 kinase for consideration as potential inhibitors.

 

Keywords

drug re-profiling, Pim-1 kinase, small kinases inhibitors

 

Citation

Arrouchi et al. Bioinformation 15(2): 116-120 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.