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Title

Structural insights from water-ferredoxin interaction in mesophilic algae and halophilic archaea

 

Authors

Amal Kumar Bandyopadhyay*,1, Rifat Nawaz Ul Islam2,$, Debanjan Mitra1,$, Sahini Banerjee3,$ & Arunava Goswami3

 

Affiliation

1Department of Biotechnology, The University of Burdwan, Burdwan, West Bengal, India; 2Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India; 3Department of Biological Sciences, ISI, Kolkata, West Bengal, India; $equally contributed;

 

Email

Amal Kumar Bandyopadhyay E-mail: akbanerjee@biotech.buruniv.ac.in; *corresponding author

 

Article Type

Research Article

 

Date

Received January 9, 2019; Revised February 11, 2019; Accepted February 11, 2019; Published February 28, 2019

 

Abstract

We analyzed the water-ferredoxin interaction in mesophilic (moderate temperature) algae (PDB ID: 1AWD) and halophilic (salt-tolerant) archaea (PDB ID: 1DOI) using POWAIND version 2.0 (a protein-water interactions calculation program). It is found that the shell water (SW) is 2.5 fold greater in halophilic ferredoxin than mesophilic ferredoxin. Water-ferredoxin interactions in the core and cavity are the signature of stability. The normalized frequency of such interactions is less in halophilic relative to mesophilic ferredoxin and the halophilic signature for stability by such interactions is negligible. However, the surface dominated with such interactions seems to be important for ferredoxin and oxido-reductase recognition.

 

Keywords

Bound-waters; interior bound waters; cavity bound waters; bridge interactions; halophilic signature; ferredoxin recognition

 

Citation

Bandyopadhyay et al. Bioinformation 15(2): 79-89 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.