Title

Phytochemicals as alternatives to antibiotics against major pathogens involved in bovine respiratory disease (BRD) and bovine mastitis (BM)

Authors

Karthic Rajamanickam, Jian Yang* & Meena Kishore Sakharkar*

Affiliation

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada

Email

Karthic Rajamanickam - karthic.champ@gmail.com; Jian Yang – Phone: +1-306-966-6361; Email: jian.yang@usask.ca; Meena Kishore Sakharkar – Phone: +1-306-966-7660; Email: meena.sakharkar@usask.ca *Corresponding author

Article Type

Research Article

Date

Received January 19, 2019; Revised January 26, 2019; Accepted January 26, 2019; Published February 3, 2019

Bovine respiratory disease (BRD) and bovine mastitis (BM) are the most common and costly infectious diseases in beef cattle and dairy cattle, respectively. In the current study, we evaluated the antimicrobial activity of seven phytochemicals against twelve BRD- and/or BM causing bacterial pathogens. Our results show that allyl isothiocyanate, benzyl isothiocynate, cinnamaldehyde and eugenol are effective against most of the BRD- and/or BM-causing bacterial pathogens and could be repurposed as alternatives to antibiotics for the prevention/elimination of BRD and BM in feedlots.

Keywords

Bovine respiratory disease; bovine mastitis; bacterial pathogen; phytochemical; MIC

Citation

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.