Title

Genome-wide codon usage bias analysis in Beauveria bassiana

Authors

Prajna Muthabathula^1,*, Saragadam Suneetha¹, J. Ratna Grace²

Affiliation

¹Department of Botany, Andhra University, Visakhapatnam, Andhra Pradesh, India; ²Department of Botany, Dr. V. S. Krishna Government Degree College, Visakhapatnam, Andhra Pradesh, India;

Email

Prajna Muthabathula - Email: prajna.muthabathula @gmail.com; Phone: +91 9618426005; *Corresponding author

Article Type

Hypothesis

Date

Received October 12, 2018; Revised October 27, 2018; Accepted October 27, 2018; Published December 28, 2018

Codon usage bias analysis allows in identifying the factors that are influencing and contributing to shape the evolution of the organisms. Therefore, it is of interest to analyze 10363 gene sequences from Beauveria bassiana. The GC content with 51.50% is higher than the AT content (48.50%) in B. bassiana. The fungal nuclear genes tend to be GC rich and predominantly G/C ending. Codon usage bias exhibited by B. bassiana is based on the Relative Synonymous Codon Usage (RSCU) values of 61 sense codons, of which 28 codons are with RSCU value larger than 1. Other factors like Nucleotide composition, mutational pressure and selection also has a role in shaping the codon usage bias. We identified 24 optimal codons that end with G or C. Correlation analysis suggests existence of translational efficiency of amino acids. Based on the GC3s distribution evolution of the B. bassiana genes is by the contribution of mutation pressure. ENC may be the major factor in shaping the codon usage bias. This study provides insights into the compositional selection pressure of the genes in B. bassiana.

Keywords

Beauveria bassiana, codon usage, translational efficiency, mutational pressure

Citation

Muthabathula et al. Bioinformation 14(9): 580-586 (2018)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.