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Antibacterial Activity study of Musizin isolated from Rhamnus wightii Wight & Arn.



William Raja Tharsius Raja1#, Stalin Antony2,5#, Saravana Kumar Pachaiyappan3, Jackson Amalraj3, Poorva Narasimhan, Balakrishna Keduki1, Duraipandiyan Veeramuthu3,4, Palani Perumal5*, Ignacimuthu Savarimuthu1,6*



1Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai - 600034, India; 2Division of Bioinformatics, Entomology Research Institute, Loyola College, Chennai - 600034, India; 3Division of Microbiology, Entomology Research Institute, Loyola College, Chennai - Chennai - 600034, India; 4Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies College of Science, King Saud University, Riyadh 11451, Saudi Arabia; 5Centre for Advanced Studies in Botany & Centre for Herbal Sciences, University of Madras, Guindy Campus, Chennai 600 025, India; 6International Scientific Partnership Program, King Saud University, Post Box 2455, Riyadh 1011 11451, Kingdom of Saudi Arabia; #Equal contribution



Dr. Savarimuthu Ignacimuthu E-mail:;Phone: 91-44-28178348; Fax: 91-44-28175566; Dr. Perumal Palani E-mail:; Phone: 91-44 22202763; Fax: 91-44-22202763. *Corresponding authors


Article Type




Received November 9, 2018; Revised December 3, 2018; Accepted December 3, 2018; Published December 21, 2018



The crude extracts and the compounds isolated from traditional medicinal plants are used to treat infectious diseases caused by bacteria, fungi, and viruses. An attempt has been made in the present investigation to evaluate the antibacterial activity of musizin isolated from Rhamnus wightii, (Family: Rhamnaceae) against Gram-positive (Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis), and Gram negative (Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa) bacteria. The tested compound showed more pronounced antibacterial activity against the tested pathogens than the standard antibiotics like streptomycin and gentamycin with the lowest minimum inhibitory concentration (MIC). Molecular docking analysis was performed to study the effectiveness of musizin compared to the standard antibiotics; it showed a significant interaction with the target proteins such asalgR (P. arginosa), divIVA (E. faecalis), icaA (S. aureus), plcR(B. cereus), treC (K. pneumonia) and ftsl (E. coli) and found that musizin showed higher potential with least binding energy. It has also been found that musizin had better ADMET properties than the standard drugs. Thus, musizin acts as an inhibitor of bacterial growth for consideration as a drug to treat bacterial infections.



Rhamnus wightii, Musizin, antibacterial activity, target receptors, in silico analysis



Tharsius Raja et al. Bioinformation 14(9): 511-520 (2018)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.