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Title

Comparative evaluation of anti-angiogenic effects of noscapine derivatives

 

Authors

Rajesh K. Meher1, Manas Ranjan Naik2, Banajit Bastia3, Pradeep K. Naik2*

 

Affiliation

1Department of Biotechnology & Bioinformatics, Sambalpur University, Jyoti Vihar 768 019, Sambalpur, Odisha;

2Department of Pharmacology, VSS Institute of Medical Science & Research, Burla, Sambalpur, Odisha;

3Environmental Toxicology & Electron Microscope Lab, ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi-110029, India;

 

Email

pknaik1973@gmail.com

 

Article Type

Hypothesis

 

Date

Received March 17, 2018; Revised April 6, 2018; Accepted April 6, 2018; Published May 31, 2018

 

Abstract

Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumor progression. Synthetic derivatives of anti-cancer compound, noscapine (an opium alkaloid) such as Cl-noscapine, Br-noscapine and Folate-noscapine along with two of the reference compounds, TNP-470 and paclitaxel were examined for anti-angiogenic activities by using human umbilical vein endothelial cells (HUVECs). The noscapine derivatives showed anti-angiogenic activity albeit at high concentration compared to the reference compounds. All the tested compounds inhibited angiogenesis in a dose-dependent manner; the drug concentration causing 50% inhibition of cell survival was 11.87 μM for Cl-noscapine, 6.9 μM for Br-noscapine and 6.79 μM for folate-noscapine. Besides, all the noscapine derivatives significantly inhibited cord formation (IC50 for Cl-noscapine is 50.76 μM, for Br-noscapine is 90.08 μM and for folate-noscapine is 18.44 μM) as well as migration and invasion (IC50 value of Cl-noscapine is 28.01 μM, for Br-noscapine is 19.78 μM and for folate-noscapine is 10.76 μM) of endothelial cells. Based on these results, we speculated that the inhibitory effects on human endothelial cell proliferation of noscapine derivatives might be important for anti-angiogenesis.

 

Keywords

Angiogenesis, noscapine, Cl-noscapine, Br-noscapine, folate-noscapine, TNP-470, paclitaxel

 

Citation

Meher et al. Bioinformation 14(5): 236-240 (2018)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.