Title

Structure modeling to function prediction of Uncharacterized Human Protein C15orf41

Authors

Md. Shakil Ahmed¹*, Md. Shahjaman², Enamul Kabir³, Md. Kamruzzaman⁴

Affiliation

¹Department of Statistics, University of Rajshahi, Rajshahi-6205, Bangladesh;

²Department of Statistics, Begum Rokeya University, Rangpur-5400, Bangladesh;

³School of Agricultural, Computational and Environmental Sciences, University of Southern Queensland, Australia;

⁴Data Science for Knowledge Creation Research Center, Seoul National University, Korea;

Email

shakil.statru@gmail.com;

Article Type

Hypothesis

Date

Received March 17, 2018; Revised April 29, 2018; Accepted April 29, 2018; Published May 31, 2018

The dyserythropoietic anemia disease is a genetic disorder of erythropoiesis characterized by morphological abnormalities of erythroblasts. This is caused by human gene C15orf41 mutation. The uncharacterized C15orf41 protein is involved in the formation of a functional complex structure. The uncharacterized C15orf41 protein is thermostable, unstable and acidic. This is associated with TPD (Treponema Pallidum) domain (135 to 265 residue position) and three PTM sites such as K50 (Acetylation), T114 (Phosphorylation) and K176 (Ubiquitination). C15orf41 is paralogous to isoform-1 (gi|194018542|) and open reading frame isoform-CRA_c (gi|119612744|) of Homo sapiens located at chromosome 15. It interacts with the human ATP (Adenosine Triphosphate) binding domain 4 (ATPBD4) having similarity score 0.725 as per protein-protein interaction (PPI) network analysis. This data provides valuable insights towards the functional characterization of human gene C15orf41.

Keywords

Uncharacterized human protein C15orf41, Phylogenetic analysis, Protein domain, PTM sites and PPI networks.

Citation

Ahmed et al. Bioinformation 14(5): 206-212 (2018)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.