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Title

Insights from the Molecular dynamics simulation of BcsD Subunit from K. xylinus

 

Authors

Simranjit Kaur1, Mahesh Kulharia2*

 

Affiliation

1Centre for Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda - 151001, India;

2Centre for Computational Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda - 151001, India;

 

Email

simranjit.kaur22@ymail.com, kulharia@gmail.com;

 

Article Type

Hypothesis

 

Date

Received November 3, 2017; Revised November 4, 2017; Accepted November 4, 2017; Published November 30, 2017

 

Abstract

Biofilms are bacteria living in micro-colonies with a protective coating in sessile form. The biofilm protects bacteria from harsh surroundings as well as help in antibiotics resistance using a semi-fluid substance. Cellulose is the major component of biofilm, which provides the sticky appearance to bacteria for attaching to the substratum. The bacteria communicate in biofilm with the help of quorum sensing hormones Acylated Homoserine Lactones (AHLís). In Komagataeibacter xylinus the four genes Bcs A, Bcs B, Bcs C, Bcs D are associated with cellulose biosynthesis. The Bcs D subunits have a hypothetical octamer pore-like structure through which glucan molecule pass to form the cellulose. Therefore, it is of interest to document a structural understanding of Bcs D. Hence a homology model of Bcs D was simulated and analyzed further to gain functional insight towards biofilm formation.

 

Keywords

AHLís, Bcs, Homology Modeling, Bacterial Biofilms.

 

Citation

Kaur & Kulharia. Bioinformation 13(11): 376- 379(2017)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.