Title

Designing of a penta-peptide against drug resistant E. coli

Authors

Sachin Nagra¹, Deepak Kumar², Rajasri Bhattacharyya^3,*, Dibyajyoti Banerjee^2,*, Tapan Mukherjee¹

Affiliation

¹Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, haryana 133207;

²Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012;

³past: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, haryana 133207;

present: Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012.

Email

dibyajyoti5200@yahoo.co.in

Article Type

Hypothesis

Date

Received May 5, 2017; Revised May 5, 2017; Accepted June 5, 2017; Published June 30, 2017

Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. In this context we have designed a peptide that fits better at the ligand-binding site of mutant PBP5 compared to wild type PBP5. It is expected that the designed peptide will halt the growth of drug resistant pathogen harboring mutant variety of PBP5. We have recommended experimental validation of the above concept.

Keywords

antibiotic resistant penicillin binding protein, antimicrobial peptide, peptide designing

Citation

Nagra et al. Bioinformation 13(6): 192-195 (2017)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.