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Title

Polymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women

 

Authors

Maniraja Jesintha Mary1,*, Lakshmanan Saravanan2, Munuswamy Deecaraman1, Melantharu
Vijayalakshmi1, Vetrivel Umashankar3, Jaigopal Sailaja4

 

Affiliation

1Dr. MGR Educational and Research Institute, Maduravoyal, Chennai;

2ARC International Fertility Research Center, Perambur, Chennai;

3Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Sankara Nethralaya Research Institute, Chennai,

4Genes N Life Healthcare, Hyderabad;

 

Email

jesintha_21@yahoo.com

 

Article Type

Hypothesis

 

Date

Received March 24, 2017; Accepted April 5, 2017; Published May 31, 2017

 

Abstract

Polycystic Ovary syndrome (PCOS) is the most common endocrine disorder affecting 5 10% of all women of reproductive age group. The present research was carried out to study the impact of Plasminogen Activator Inhibitor (PAI-1) 4G/5G polymorphism (rs1799889) in PCOS, and the risk of developing PCOS in South Indian Population. The study was carried out in 60 subjects of South Indian population (30 PCOS and 30 Non PCOS) recruited from ARC Research and Fertility Centre, Chennai, India. Genotype and Allelic frequencies were compared by Fisher exact test, Hardy Weinberg equilibrium. p<0.05 was considered statistically significant. The Genotype frequency difference between PCOS and non-PCOS was observed as statistically non-significant (p=0.4647, OR=1.3077, 95% CI 0.63-2.68). The allelic frequency distribution in Spontaneous Abortion (SAB) cases in total subjects is not found to be statistically significant (p=0. 29), however the PCOS women carrying mutant homozygous and heterozygous genotype are more prone to recurrent pregnancy loss. Out of 17 Implantation failure cases, 23.52% were found to carry mutant homozygous (4G/4G), and 66.66% carried mutant heterozygous (4G/5G), and 5.88% carried wild type homozygous (5G/5G), the allelic difference was highly significant with 4G (62.5%), and 5G (37.5%). P value is highly significant and recorded at p=0.0164. The positive correlation between PAI-1 4G/5G polymorphism and PCOS risk was not observed in this study, however, the correlation between Recurrent Pregnancy Loss (RPL) and Implantation failures were observed in PCOS cases.

 

Keywords

PCOS; Polycystic Ovary Syndrome; PA1-1; Polymorphism

 

Citation

Jesintha Mary et al. Bioinformation 13(5): 149-153 (2017)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.