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Title

Sequence to functional analysis of LPAR6 mutants using structural molecular models

 

Authors

Samina A. Khan

 

Affiliation

Medical Education Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia;

 

Email

*Samina A. Khan- Email: samina.amanullah@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received August 2, 2016; Revised December 21, 2016; Accepted December 22, 2016; Published December 30, 2016

 

Abstract

The human hair has compound structures with several known biological functions. Hereditary hair loss is caused by a heterogeneous group of disorders. LPAR6 gene is associated with hair loss or baldness, which is characterized by sparse scalp hair, sparse to absent eyebrows and eyelashes, and sparse auxiliary and body hair. Mutant variants of LPAR6 gene and its corresponding P2RY5 protein sequences are available in GenBank. Therefore, it is of interest to study their mutational effect in these variants using P2RY5 protein homology based molecular models (Protein Model Database (PMDB) ID: PM0077839). The differences in subtle structural features with calculated physiochemical properties in various P2RY5 protein variants are documented in this study using mutant models. This data will provide insight in the understanding of cellular functions responsible for the growth of hair follicles with reference to baldness in human.

 

Keywords

LPAR6, P2RY5, structure prediction, hair loss, trans-membrane segmentation

 

Citation

Khan, Bioinformation 12(12): 430-435 (2016)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.