Title

Microarray Integrated Analysis of a Gene Network for the CD36 Myocardial Phenotype

Authors

Imane Sabaouni1,*, Brigitte Vannier2, Ahmed Moussa3 & Azeddine Ibrahimi1

Affiliation

1Medical Biotechnology Lab (MedBiotech), Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Morocco; 2Receptors, Regulation and Tumor Cells (2RTC) Laboratory, University of Poitiers, France; 3LabTIC Laboratory, ENSA, Abdelmalek Essaadi University, Tangier, Morocco

Email

Imane SABAOUNI – E-mail: imanesabaouni@yahoo.com *Corresponding author

Article Type

Hypothesis

Date

Received July 18, 2016; Revised July 29, 2016; Accepted July 30, 2016; Published October 11, 2016

CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). However, much remains to be understood about the molecular mechanism of the cardio-myopathy observed in CD36-KO mice. In this study, we identify different genes pathways involved in response to CD36 cardio-myopathy phenotype by identifying the differences among biological processes, molecular pathways and networks of interactions that emerge from knocking CD3 and using different bioinformatics tools such as STRING, GeneMANIA and Cytoscape. We were able list all the CD36-regulated genes, their related function and their specific networks. Data analysis showed that CD36-regulated genes differentially expressed are involved in
biological processes such as FA metabolism, angiogenesis/apoptosis and cell structure. These results provide the first look at mechanisms involved in CD36 deficiency and development of cardio-myopathy and the opportunity to identify new therapeutic targets.

Keywords

CD36, cardio-myopathy, genes networks, genes pathways, metabolism, angiogenesis/apoptosis.

Citation

Sabaouni et al. Bioinformation 12(6): 332-339 (2016)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.