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Title |
Allele frequency for Cystic fibrosis in Indians vis-a/-vis global populations |
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Authors |
Karnajit Kumar Bepari, Arup Kumar Malakar, Prosenjit Paul, Binata Halder & Supriyo Chakraborty* |
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Affiliation |
Department of Biotechnology, Assam University, Silchar 788011, Assam, India
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supriyoch_2008@rediffmail.com; *Corresponding author
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Article Type |
Hypothesis
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Date |
Received July 02, 2015; Revised July 23, 2015; Accepted July 24, 2015; Published July 31, 2015
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Abstract |
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. This gene encodes a protein involved in epithelial anion channel. Cystic fibrosis is the most common life-limiting genetic disorder in Caucasians; it also affects other ethnic groups like the Blacks and the Native Americans. Cystic fibrosis is considered to be rare among individuals from the Indian subcontinent. We analyzed a total of 29 world’s populations for cystic fibrosis on the basis of gene frequency and heterozygosity. Among 29 countries Switzerland revealed the highest gene frequency and heterozygosity for CF (0.022, 0.043) whereas Japan recorded the lowest values (0.002, 0.004) followed by India (0.004, 0.008). Our analysis suggests that the prevalence of cystic fibrosis is very low in India.
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Keywords |
Allele frequency, cystic fibrosis, India, other populations.
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Citation |
Bepari et al.
Bioinformation 11(7): 348-352(2015) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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