Examining and elucidation of human weight cycle model adopting e-cell simulation system

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Title	Examining and elucidation of human weight cycle model adopting e-cell simulation system
Authors	Durairaj Rajesh¹, Subramanian Muthukumar¹, Durairaj Siva², Ganesan Saibaba¹, Dharumadhurai Dhanasekaran³ & Govindaraju Archunan¹*
Affiliation	¹Centre for Pheromone Technology, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli – 620 024, Tamil Nadu, India; ²Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli – 620 024; Tamil Nadu, India; ³Department of Microbiology, Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, India
Email	garchu56@yahoo.co.in; *Corresponding author
Article Type	Hypothesis
Date	Received October 15, 2014; Accepted November 12, 2014; Published July 31, 2015
Abstract	Cellular rhythms regulate various physiological functions in circadian oscillatory mechanisms. Weight cycling or ‘yo-yo’ dieting is an evitable process in human, because of subsequent loss and regain of body weight due to irregular diet. Human weight cycle (HWC) is the major factor for causing global epidemic diseases in human beings. Understanding the HWC process would provide potent additional knowledge to prevent obesity. However till date, there is no study dealing with examine the HWC model using virtual cell simulation based on system biological approach. Therefore, the present study was designed to develop a computational HWC model, which was simulated using E-cell system v3.0. The developed model has the cyclic feedback reactions of three significant variables (the consecutive cycles of weight loss in continuous food intake (Q) and regain of body weight (P) at highest threshold point of cognitive restraint (R)) which are obtained by mathematical modelling. The dynamic plot results supported that the PQR variables depicted sustained oscillation with reversible modification due to protein diet. By contrast, the virtual model simulation would provide extensive information on HWC, which might provide knowledge to develop HWC linked with obesity pathway. The presents study concludes that optimization of body weight is essential to prevent the obesity based diseases.
Keywords	Human weight cycle (HWC) model, yo-yo diet, Goldbeter model, PQR, E-CELL system
Citation	Rajesh et al. Bioinformation 11(7): 336-342 (2015)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.