Title |
Disease associated cellular machinery in anaphylaxis – And the de novo paradigm shift |
Authors |
Peter Natesan Pushparaj1*, Mahmood Rasool1, Muhammad Imran Naseer1, Laila Abdullah Damiati2, Narasimhan Kothandaraman1, Kalamegam Gauthaman1, Sami Bhalas3 & Jayapal Manikandan4 |
Affiliation |
1Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 2King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 3Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 4Faculty of Life and Physical Sciences, The University of Western Australia (M011), 35 Stirling Highway, Crawley, WA 6009, Australia
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peter.n.pushparaj@gmail.com; *Corresponding author
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Article Type |
Review
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Date |
Received December 25, 2014; Accepted January 13, 2015; Published January 30, 2015
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Abstract |
Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS.
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Keywords |
Anaphylaxis, Anaphylactic shock, Immunoglobulin E, Mast cells, Cytokines, Chemokines, Paradigm shift
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Citation |
Pushparaj et al. Bioinformation 11(1): 043-046 (2015)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |