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Title

Disease associated cellular machinery in anaphylaxis And the de novo paradigm shift

 

Authors

Peter Natesan Pushparaj1*, Mahmood Rasool1, Muhammad Imran Naseer1, Laila Abdullah Damiati2, Narasimhan Kothandaraman1, Kalamegam Gauthaman1, Sami Bhalas3 & Jayapal Manikandan4

 

Affiliation

1Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 2King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 3Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 4Faculty of Life and Physical Sciences, The University of Western Australia (M011), 35 Stirling Highway, Crawley, WA 6009, Australia

 

Email

peter.n.pushparaj@gmail.com; *Corresponding author

 

Article Type

Review

 

Date

Received December 25, 2014; Accepted January 13, 2015; Published January 30, 2015

 

Abstract

Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS.

 

Keywords

Anaphylaxis, Anaphylactic shock, Immunoglobulin E, Mast cells, Cytokines, Chemokines, Paradigm shift

 

Citation

Pushparaj et al. Bioinformation 11(1): 043-046 (2015)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.