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Title

Alkyloxy carbonyl modified hexapeptides as a high affinity compounds for Wnt5A protein in the treatment of psoriasis

 

Authors

Ankit Kelotra1*, Sadashiv M Gokhale1, Seema Kelotra2, Vaidehi Mukadam4, Komal Nagwanshi4, Srinivas Bandaru3, Anuraj Nayarisseri4 & Anil Bidwai5

 

Affiliation

1School of Biochemistry, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore (M.P.) 452 017, India; 2M.B Khalsa College, Near Gangwal Bus Stand, Indore (M.P.)-452011, India; 3Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad 500 016, India; 4In silico Research Laboratory, Eminent Biosciences, Indore 452 010, India; 5Index medical College, Indore (M.P)-452010, India

 

Email

ankitkelotra22@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received December 18, 2014; Accepted December 24, 2014; Published December 31, 2014

 

Abstract

Psoriasis is one of the most prevalent chronic inflammatory diseases of the skin. The Wnt pathways have been documented to play essential role in stem cell self-renewal and keratinocyte differentiation in the skin. Antagonizing the Wnt5a protein would emerge as a novel therapeutics in psoriasis treatment. In this view, we have developed and characterized series of compounds by attaching varied tertiary alkyloxy carbonyl groups at the N-terminal end of the hexapeptide (Met-Asp-Gly-Cys-Glu-Leu) bestowed to inhibit Wnt/Ca2+ signaling in psoriasis. Hexapeptide compound with 1,1-diphenylethoxy carbonyl group attached to N-terminal end of hexapeptide demonstrated highest binding affinity amongst all the evaluated compounds. The compound identified in the study can be subjected further for in vitro and in vivo studies for ADMET properties.

 

Keywords

Psoriasis, Wnt5A, Protein Modeling, Alkyloxy carbonyl modified hexapeptides, Molecular docking

 

Citation

Kelotra  et al. Bioinformation 10(12): 743-749 (2014)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.