Anti-fungal resistance in candida isolated from oral and diaper rash candidiasis in neonates

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Title	Anti-fungal resistance in candida isolated from oral and diaper rash candidiasis in neonates
Authors	Jasem Mohamadi¹, Mahsa Motaghi², Jafar panahi³, Mohamad Reza Havasian³, Ali Delpisheh⁴, Mitra Azizian² & Iraj Pakzad^2,5*
Affiliation	¹Department pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran; ²Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran; ³Student research of committee, Ilam University of Medical Sciences, Ilam/ Iran; ⁴Department Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran; ⁵Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam/ Iran
Email	Pakzad_i2006@yahoo.com; *Corresponding author
Article Type	Hypothesis
Date	Received October 04, 2014; Accepted October 28, 2014; Published November 27, 2014
Abstract	The purpose of the present study is to evaluate the sensitivity of Candida species isolated from oral candidiasis and diaper dermatitis infections in children. The children referring to private and public clinics in Ilam, Iran were exmined for oral candidiasis and diaper dermatitis. In this study, 248 oral candidiasis and diaper dermatitis samples were collected and cultured.Candida species were identified by using standard methods. Resistance and sensitivity to amphotericin B, nystatin, ketoconazole, fluconazole, itraconazole, clotrimazole, and posaconazole were determined using the CLSI M44-A standard disk diffusion method. From the 248 studied samples, 149 were positive for Candida, among which the Candida albicans was the most prevalent (64.4%). The resistance of different Candida species to nystatin, itraconazole, fluconazole, ketoconazole, clotrimazole, voriconazole, and posaconazole were 4, 43, 34.2, 34.9, 21.5, 6, and 6.7%, respectively. No resistance to amphotericin B was observed. Considering rather low resistance to nystatin, this drug is the best choice for oral candidiasis and diaper dermatitis.
Keywords	Drug resistance, Oral candidiasis, Diaper dermatitis.
Citation	Mohamadi et al. Bioinformation 10(11): 667-670 (2014)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.