Title

Authors

Affiliation

¹Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil; ²Centro Universitário do Pará - Área de Ciências Exatas e Tecnologia, , Belém, PA, Brasil; ³Universidade Federal Rural da Amazônia, Campus de Capanema, PA, Brasil; ⁴Nucleo de Pesquisa em Oncologia, Universidade Federal do Para, Belem, PA, Brasil

Email

akely@ufpa.br/akelyufpa@gmail.com; *Corresponding authors

Article Type

Software

Date

Received July 29, 2014; Accepted August 01, 2014; Published September 30, 2014

MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.

Availability

http://lghm.ufpa.br/targetcompare

Keywords

miRNA, Gastric Cancer, Bioinformatics, Web tool, Target Genes.

Citation

Moreira  et al. Bioinformation 10(9): 602-605 (2014)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.