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TargetCompare: A web interface to compare simultaneous miRNAs targets



Fabiano Cordeiro Moreira1,2, Bruno Dustan1,2, Igor G Hamoy1,3, André M Ribeiro-dos-Santos1 & Ândrea Ribeiro dos Santos1,4*



1Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil; 2Centro Universitário do Pará - Área de Ciências Exatas e Tecnologia, , Belém, PA, Brasil; 3Universidade Federal Rural da Amazônia, Campus de Capanema, PA, Brasil; 4Nucleo de Pesquisa em Oncologia, Universidade Federal do Para, Belem, PA, Brasil


Email; *Corresponding authors


Article Type




Received July 29, 2014; Accepted August 01, 2014; Published September 30, 2014



MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.





miRNA, Gastric Cancer, Bioinformatics, Web tool, Target Genes.



Moreira  et al. Bioinformation 10(9): 602-605 (2014)

Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.