Title

Authors

Affiliation

¹Environmental Carcinogenesis Division, CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, P Box 80, Lucknow-226001; ²Environmental Carcinogenesis & Toxicoinformatics Laboratory, Departments of Biosciences, Integral University, Lucknow-226026

Email

mlohani@rediffmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received July 18, 2014; Revised August 03, 2014; Accepted August 04, 2014; Published August 30, 2014

Arsenic is the most toxic metalloid present in the natural environment in both organic and inorganic arsenic forms. Inorganic arsenic is often more hazardous than the organic form. Arsenite and arsenate compounds are the major inorganic forms which are toxic causing severe human health dysfunction including cancer. Excretion of arsenic from the system is found elusive. Therefore, it is of interest to screen channel proteins with the arsenic complex in the different combination of arsenic, GSH (glutathione) and arsenic, selenium using docking methods. The mode of arsenic removal. The complex structure revealed the mode of arsenic binding efficiency with the receptor aquaporine 9 and ABCC1 channel protein. This provides insights to understand the mechanism of arsenic efflux. These inferences find application in the design, identification and development of novel nutracetucal or any other formulation useful in the balance of arsenic efflux.

Keywords

Arsenic toxicity, Molecular Docking, Transport Channels.

Citation

Poojan et al.   Bioinformation 10(8): 474-479 (2014)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.