Title

Authors

Affiliation

Department of Molecular Biology & Genetic Engineering, College of Basic Sciences & Humanities, G. B. Pant University of Agriculture & Technology, Pantnagar-263145 (Uttarakhand), India

Email

gohartajkhan@rediffmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received October 10, 2013; Revised November 13, 2013; Accepted December 18, 2013; Published December 27, 2013

Protein-Protein interactions (PPIs) are vital to most biological processes thus the identification of PPIs is of primary importance. Here, we endeavor to identify the downstream interacting partners of (BjMPK3P) in Brassica juncea using the docking approach. Out of 63 and 37 members of BrWRKY and BnWRKY transcription factors, 50 and 29 members are showing interactions with BjMPK3P respectively while the rest are showing non-interaction. Twenty two WRKY members are common to both the species. Using minimal sequence motif search as well as through docking approach several novel WRKY interacting proteins were also reported in the present study which need to be confirmed by in vitro kinase assay. Together, the results obtained essentially enhance our knowledge of the MAPK interacting protein network and provide a valuable research resource for developing a nearly important link between pathogen-activated MAPK signaling pathways and downstream transcriptional programming.

Keywords

Protein -Protein interactions (PPIs), Transcription factor (TF), docking, MAPK.

Citation

Giri et al.  Bioinformation 9(20): 1036-1039 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.