Title

Authors

Affiliation

¹Department of CSE, VR Siddhartha Engineering College, VR Siddhartha Engineering College, Kanuru, Vijayawada, ²Department of CSE, Mahatma Gandhi Institute of Technology,  Gandipet, Hyderabad;

Email

drvsrao9@gmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received November 10, 2013; Accepted November 25, 2013; Published December 06, 2013

Alzheimer's disease (AD) is the most common form of dementia. It is the sixth leading cause of death in old age people. Despite recent advances in the field of drug design, the medical treatment for the disease is purely symptomatic and hardly effective. Thus there is a need to understand the molecular mechanism behind the disease in order to improve the drug aspects of the disease. We provided two contributions in the field of proteomics in drug design. First, we have constructed a protein-protein interaction network for Alzheimer's disease reviewed proteins with 1412 interactions predicted among 969 proteins. Second, the disease proteins were given confidence scores to prioritize and then analyzed for their homology nature with respect to paralogs and homologs. The homology persisted with the mouse giving a basis for drug design phase. The method will create a new drug design technique in the field of bioinformatics by linking drug design process with protein-protein interactions via signal pathways. This method can be improvised for other diseases in future.

Keywords

Alzheimer’s disease, protein network, protein interactions, protein interaction network, PPI for Alzheimer’s, PPI network, Alzheimer’s disease network.

Citation

Rao et al. Bioinformation 9(19): 968-972 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.