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Title

Sequence analysis, structure and binding site prediction of Sigma 1 receptor protein by in silico method

 

Authors

Narayanasamy Lokeswaran Latha1, Garimella Gyananath1* & Pudukulathan Kader Zubaidha2

 

Affiliation

1School of Life Sciences, S. R. T. M. University, Nanded - 431606, India; 2Chemical Sciences, S. R. T. M. University, Nanded-431606, India

 

Email

gyananath52@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received October 25, 2013; Accepted November 03, 2013; Published December 06, 2013

 

Abstract

Sigma 1 Receptor is a subtype of opioid receptor that participates in membrane remodeling and cellular differentiation in the nervous system. Sigma1 Receptor protein with amino acid length ranging from 229 is widely distributed in the liver and moderately in the intestine, kidney, white pulp of the spleen, adrenal gland, brain, placenta and the lung. In this study, the three dimensional structure for sigma 1 receptor protein has been developed by in- silico analysis based on evolutionary trace analysis of 37 sigma proteins from different sources. The present work focus on identification of functionally important residues and its interaction with antipsychotic drugs reported in literature. 

 

Keywords

Sigma receptor, Evolutionary trace, Binding sites.

 

Citation

Latha et al. Bioinformation 9(19): 944-951 (2013)

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.