Title

Authors

Affiliation

¹Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India; ²Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Email

dibyajyoti5200@yahoo.co.in; *Corresponding author

Article Type

Hypothesis

Date

Received September 07, 2013; Accepted September 08, 2013; Published September 23, 2013

Diabetes mellitus is considered as a predisposition factor for active tuberculosis and is known to activate the latent form of tuberculosis. However, the causative association of latent tuberculosis with diabetes is not conclusively established. Therefore, it is of interest to relate their predisposition. We describe the glycation pattern of mescenchymal stem cell surface markers as CD271+/CD45-mescenchymal stem cell is known to be associated with latent tuberculosis. We show that the lysine residues important for function of CD271 death domain are predicted to be and glycated. These observations help to discuss the role of CD271 and glycation to modulate the genesis of latent tuberculosis in chronic diabetic mellitus.

Keywords

Diabetes Mellitus; active tuberculosis, latent tuberculosis, mesenchymal stem cell markers, glycation.

Citation

Bhattacharyya  et al.   Bioinformation 9(16): 829-831 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.