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Title

Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra

 

Authors

Ankit Verma, Dhirendra Kumar Sharma*, Rituparna Sarma, Hasnahana Chetia & Juri Saikia

 

Affiliation

Bioinformatics Infrastructure Facility, Gauhati University, Guwahati - 781014, Assam, India

 

Email

dksgu@yahoo.co.uk; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received August 07, 2013; Accepted August 08, 2013; Published August 28, 2013

 

Abstract

BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy. 

 

Citation

Verma et al. Bioinformation 9(15): 755-758 (2013)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.