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Title

Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline

 

Authors

Satyanarayana Rentala1, Sudhakar Konada1*, Ramakrishna Chintala2, Lakshmi Narasu Mangamoori3, Suryanarayana Murthy Upadhyayula4 & Sarva Mangala Dhurjeti1

 

Affiliation

1Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam 530 045, INDIA; 2Department of Environmental Studies, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, INDIA; 3Department of Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad 500085, INDIA; 4Associate professor of ophthalmology, Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh, INDIA

 

Email

sudha.1930@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received July 17, 2013; Revised July 20, 2013; Accepted July 20, 2013; Published August 07, 2013

 

Abstract

Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.

 

Keywords

Cataract formation, Oxidative stress, gamma-D-crystallin, Anti-oxidants, Docking scores.

 

Citation

Rentala et al.  Bioinformation 9(14): 721-724 (2013)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.