Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline

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Title	Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline
Authors	Satyanarayana Rentala¹, Sudhakar Konada¹*, Ramakrishna Chintala², Lakshmi Narasu Mangamoori³, Suryanarayana Murthy Upadhyayula⁴ & Sarva Mangala Dhurjeti¹
Affiliation	¹Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam – 530 045, INDIA; ²Department of Environmental Studies, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam – 530 045, INDIA; ³Department of Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad – 500085, INDIA; ⁴Associate professor of ophthalmology, Rajiv Gandhi Institute of Medical Sciences, Srikakulam, Andhra Pradesh, INDIA
Email	sudha.1930@gmail.com; *Corresponding author
Article Type	Hypothesis
Date	Received July 17, 2013; Revised July 20, 2013; Accepted July 20, 2013; Published August 07, 2013
Abstract	Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.
Keywords	Cataract formation, Oxidative stress, gamma-D-crystallin, Anti-oxidants, Docking scores.
Citation	Rentala et al. Bioinformation 9(14): 721-724 (2013)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.