Title

Authors

Affiliation

¹DST-FIST Bioinformatics & Principal Investigator, School of Genomics, Department of Advanced Zoology and Biotechnology, Loyola College, Chennai – 600 034, Tamil Nadu, India; ²Department of Chemistry, Islamiah College, Vaniyambadi - 635752, Tamil Nadu, India; ³Bioinformatics Infrastructure Facility, CAS in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai – 600 025, Tamil Nadu, India

Email

dsloy2003@gmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received April 06, 2013; Accepted April 08, 2013; Published May 25, 2013

Transfer RNA (tRNA) structure, modifications and functions are evolutionary and established in bacteria, archaea and eukaryotes. Typically the tRNA modifications are indispensable for its stability and are required for decoding the mRNA into amino acids for protein synthesis. A conserved methylation has been located on the anticodon loop specifically at the 37th position and it is next to the anticodon bases. This modification is called as m1G37 and it is catalyzed by tRNA (m1G37) methyltransferase (TrmD). It is deciphered that G37 positions occur on few additional amino acids specific tRNA subsets in bacteria. Furthermore, Archaea and Eukaryotes have more number of tRNA subsets which contains G37 position next to the anticodon and the G residue are located at different positions such as G36, G37, G38, 39, and G40. In eight bacterial species, G (guanosine) residues are presents at the 37th and 38th position except three tRNA subsets having G residues at 36th and 39th positions. Therefore we propose that m1G37 modification may be feasible at 36th, 37th, 38th, 39th and 40th positions next to the anticodon of tRNAs. Collectively, methylation at G residues close to the anticodon may be possible at different positions and without restriction of anticodon 3rd base A, C, U or G.

Keywords

tRNAs, Codon, Anticodon, m¹G modification

Citation

Srinivasan et al.   Bioinformation 9(9): 466-470 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.