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Title

Molecular signaling cascade of miRNAs in causing Diabetes Nephropathy

 

Authors

Dyave Gowda Padmashree & Narayanaswamy Ramachandra Swamy*

 

Affiliation

Department of Biochemistry, Central College Campus, Bangalore University, Bangalore 560 001

 

Email

drnrswamy@yahoo.com; *Corresponding authors

 

Article Type

Hypothesis

 

Date

Received April 15, 2013; Accepted April 16, 2013; Published April 30, 2013

 

Abstract

Diabetic nephropathy (DN) is one of the major microvascular diseases and most common in diabetic patient, finally results in kidney failure. The main features of DN are basement membrane thickening, microalbuminuria, proteinuria, glomerular, mesangial hypertrophy and ECM protein accumulation. Recent discoveries have been shown that numerous pathways are activated during the development of DN in Diabetes mellitus. The small non-coding miRNA plays an important role in regulating the pathway which is involved in DN. In our study we consolidate different pathways which regulated by miRNAs in molecular signaling which results in causing DN. We embedded entire pathway in the form of regulatory network and we could able to understand that some of the miRNAs like miR-29 family, miR-377 and miR-25 would be able to control DN.

 

Citation

Padmashree & Swamy, Bioinformation 9(8): 401-408 (2013)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.