Title

Authors

Affiliation

Department of Obstetrics and Gynecology, King Khalid University Hospital, College of Medicine, King Saud University P.O. Box 60826, Riyadh 11555, Kingdom of Saudi Arabia

Email

drzeinab@yahoo.com; *Corresponding author

Article Type

Hypothesis

Date

Received April 05, 2013; Accepted April 08, 2013; Published April 30, 2013

Preimplantation genetic diagnosis (PGD) testing is the practice of obtaining a cellular biopsy sample from a developing human oocyte or embryo, acquired via a cycle of in vitro fertilization (IVF); evaluating the genetic composition of this sample; and using this information to determine which embryos will be optimal for subsequent uterine transfer. PGD has become an increasingly useful adjunct to IVF procedures. The ability to provide couples who are known carriers of genetic abnormalities the opportunity to deliver healthy babies has opened a new frontier in reproductive medicine. The purpose of the PGD is enables us to choose which embryos will be implanted into the mother. In the present study 137 families who had undergone IVF at Habib Medical Centre, were enrolled for the PGD analysis. The couple visited the clinic for the sex selection, recurrent fetal loss and with the recurrent IVF failure. 802 embryos were tested by the biopsy method and 512 are found to be normal and 290 were abnormal embryos. In this study only 24% of the embryos were transferred and the remaining was not transferred because of the abnormalities or undesired sex of the embryos. The structural and numerical abnormalities were found to be 16.8%. 

Keywords

Preimplantation genetic diagnosis (PGD), invitro fertilization (IVF), Biopsy, Saudi Arabia.

Citation

Abotalib,  Bioinformation 9(8): 388-393 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.