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Title

Docking studies of piperine - iron conjugate with human CYP450 3A4

 

Authors

Veerabrahmam Alugolu1*, Satyanarayana Rentala2, Aruna Lakshmi Komarraju2 & Uma Devi Parimi3

 

Affiliation

1Department of Microbiology, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, INDIA; 2Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam 530 045, India; 3Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, India

 

Email

alu.veer@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received March 06, 2013; Accepted March 06, 2013; Published April 13, 2013

 

Abstract

Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates. However, there areno evidences on piperine-iron conjugate to inhibit human CYP450 3A4. We therefore investigated the influence of piperine-Fe conjugate to study the metabolism of iron with CYP450 3A4. Our in silico results showed that Piperine when conjugated with iron, inhibited activity of CYP450 3A4. This improved the binding of piperine-Fe conjugate with CYP450 3A4 and increased bioavailability. 

 

Keywords

Bioavailability, metabolic enzymes, Cytochrome P450 isoenzymes, piperine-iron conjugate and docking scores.

 

Citation

Alugolu et al. Bioinformation 9(7): 334-338 (2013)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.