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Title

Role of highly central residues of P-loop and itís flanking region in preserving the archetypal conformation of Walker A motif of diverse P-loop NTPases

 

Authors

Ekta Pathak1, Neelam Atri2 & Rajeev Mishra1*

 

Affiliation

1Department of Bioinformatics (MMV), Banaras Hindu University, India; 2Department of Botany (MMV), Banaras Hindu University, Varanasi-221005, India.

 

Email

mishrarajeev@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received December 03, 2012; Accepted December 05, 2012; Published January 09, 2013

 

Abstract

P-loop NTPases represent a large and highly diverse protein family that is involved in variety of cellular functions. Walker A motif forms a typical arched conformation, necessary to accommodate the phosphate moiety of the nucleoside tri (or di-) phosphate in P-loop NTPases. The feature that maintains the ancient architecture of P-loop is unidentified and uncharacterized. Here, using a well established global network parameter, closeness centrality, we identify that Walker A and its flanking regions (N- and C-terminal) have high density of globally connected residue positions. We find that closeness centrality of these residue positions are conserved across common structural core of diverse domains of P-loop NTPase fold. Our results suggest the potential role of globally connected residues in maintaining the local conformation of P-loop.

 

Citation

Pathak et al. Bioinformation 9(1): 023-028 (2013)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.