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Title |
Analysis of G6PD enzyme deficiency in Saudi population |
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Authors |
Khalid K Alharbi, Alaa Salem Abed, Rabbani Syed*, Imran Ali khan & Sabeena Muhammed Mustafa |
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Affiliation |
Clinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Kingdom of Saudi Arabia.
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rabbanisyd@gmail.com; *Corresponding authors
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Article Type |
Hypothesis
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Date |
Received September 19, 2012; Accepted October 17, 2012; Published December 19, 2012
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Abstract |
The evolutionary conservation of a housekeeping gene such as G6PD is greater than that of tissue-specific genes, presumably because the latter may require more specific adaptation to the physiology of individual organisms. The abundance of distinct mutation sites and their clinical manifestations make G6PD ideal for structure-function analysis. Therefore, it is of interest to screen of G6PD deficiency in the blood donors in Kingdom of Saudi Arabia. We report the mean and variation of enzyme activity in a huge set of Suadi to non-Saudi population with reference to the entire population. The sequence level conservation of G6PD among distant species is demonstrated using phylogenetic trees. These observations have implications in the sequence-structure-function understanding of G6PD with reference to its association to several human diseases.
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Keywords |
G6PD enzyme, Phylogenetic tree, Gene –Gene Distance, Mutations.
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Citation |
Alharbi et al.
Bioinformation 8(25): 1260-1264 (2012) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |