Microsatellite repeat dynamics in mitochondrial genomes of phytopathogenic fungi: frequency and distribution in the genic and intergenic regions

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Title	Microsatellite repeat dynamics in mitochondrial genomes of phytopathogenic fungi: frequency and distribution in the genic and intergenic regions
Authors	Sahil Mahfooz¹*, Pallavi Singh², Deepak K Maurya², Mahesh C Yadav³, Azram Tahoor⁴, Harmesh Sahay², Arpita Srivastava² & Anil Prakash¹
Affiliation	¹Department of Biotechnology and Bioinformatics, Barkatullah University, Bhopal 462 026, Madhya Pradesh, India; ²National Bureau of Agriculturally Important Microorganisms, Mau 275 101, Uttar Pradesh, India; ³National Research Centre on DNA Fingerprinting, National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi 110 012, India; ⁴Department of Wildlife Science, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
Email	sahil_mahfooz@yahoo.com; *Corresponding author
Article Type	Hypothesis
Date	Received November 02, 2012; Accepted November 05, 2012; Published November 23, 2012
Abstract	The frequency and distribution of microsatellites were analyzed in the 19 mitogenomes of phytopathogenic fungi covering five phyla. Our analysis revealed that in all the mitogenomes studied, the frequency and relative abundance varied, and it was neither influenced by genome size nor by GC content. SSRs were found to be differential distributed in genic and intergenic regions. An average of 5.14 (23.6%) SSRs were present in genic sequences and 21.7 (76.4%) SSRs were located in the intergenic sequences. Relative abundance of SSRs in mitogenomes was the highest in Aspergillus tubigensis, whereas, it was the least in Phaeosphaeria nodurum, the average being 0.45. Trinucleotide repeats were the most abundant motifs in the genic and intergenic regions of the mitogenomes of the phytopathogenic fungi. Among the genes, cox1 harbors the maximum SSRs, whereas cox3 and nad 7 contain the least. Based on the presence of SSRs in a particular gene, genetic relationships among individual organisms were also established.
Keywords	Simple sequence repeats, Comparative genomics, Mitochondria; Phytopathogenic fungi, Phylogenetics.
Citation	*Mahfooz et al.* Bioinformation 8(23): 1171-1175 (2012)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.