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Title

Study of human allergic milk whey protein from different mammalian species using computational method

 

Authors

Shikha Jaiprakash Dixit1, Appu Kuttan KK2 & Kiran Singh1*

 

Affiliation

1Department of Chemical Engineering and Biotechnology, Maulana Azad National Institute of Technology, Bhopal-462051, Madhya Pradesh, India; 2Maulana Azad National Institute of Technology, Bhopal.

 

Email

Researchnm.kiran@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received October 15, 2012; Accepted October 17, 2012; Published October 31, 2012

Abstract

Nowadays, safety and quality assessment of food used for human consumption have to consider by its possible contribution to the maintenance or improvement of the consumerís health. Milk is an important food with many nutrients. Cow milk is an important source of energy, protein, vitamins and minerals for the growing child as well as adults. But, numerous cow milk proteins have been implicated in allergic responses and most of these have been shown to contain multiple allergic epitopes. The present study disclosed best alternatives to cow milk, which are not allergic and as good as cow milk in nutritional value. The in silico analysis of casein (alpha s1, alpha s2, beta and kappa) and beta-lactoglobulin, unveils that sheep milk is a more suitable alternate to cow milk for allergic infants and buffalo milk for allergic adult humans.

 

Keywords

Casein, Beta-lactoglobulin, Multiple Sequence Alignment, Neighbour joining method.

 

Citation

Dixit et al. Bioinformation 8(21): 1035-1041 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.