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Title

Studies on New Delhi Metallo-Beta-Lactamse-1 producing Acinetobacter baumannii isolated from donor swab in a tertiary eye care centre, India and structural analysis of its antibiotic binding interactions

 

Authors

Murali Sowmiya1, Vetrivel Umashankar2, Sivashanmugan Muthukumaran2, Hajib Naraharirao Madhavan1 & Jambulingam Malathi1*

 

Affiliation

1L& T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, New.41 (Old.No18), Chennai 600006 India; 2Centre of Bioinformatics, Vision Research Foundation, Sankara Nethralaya, Chennai, India

 

Email

drjm@snmail.org; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received May 07, 2012; Accepted May 10, 2012; Published May 31, 2012

 

Abstract

Gram-negative bacilli, Enterobacteriaceae and Non-fermentors with resistance to carbapenems and metallo beta-lactams are the major cause of concern in clinical problems in current human healthcare. The most highly emerging dreadful Metallo Beta-lactamses is New Delhi metallo-beta-lactamase (blaNDM-1) which confers resistance to carbapenems; susceptible only to colistin and, less consistently to tigecycline, leading to no therapeutic options. In the present study, we demonstrate the effects of cephalosporins and carbepenems on biofilm producing A. baumanii clinical isolate and also to infer the probable inhibitory binding mode through molecular docking studies. The result of MIC on Biofilm producing A. baumanii and the docking analysis results were found to be concordant. Moreover, we also found cephalosporins and carbepenem groups to interact with 162-166 region of blaNDM-1, which is unique for NDM-1 and also documented to be a potential drug targeting region.

 

Citation

Sowmiya et al. Bioinformation 8(10): 445-452(2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.