Studies on New Delhi Metallo-Beta-Lactamse-1 producing <i>Acinetobacter baumannii</i> isolated from donor swab in a tertiary eye care centre, India and structural analysis of its antibiotic binding interactions

BACK TO CONTENTS | PDF | NEXT

Title	Studies on New Delhi Metallo-Beta-Lactamse-1 producing Acinetobacter baumannii isolated from donor swab in a tertiary eye care centre, India and structural analysis of its antibiotic binding interactions
Authors	Murali Sowmiya¹, Vetrivel Umashankar², Sivashanmugan Muthukumaran², Hajib Naraharirao Madhavan¹ & Jambulingam Malathi¹*
Affiliation	¹L& T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, New.41 (Old.No18), Chennai – 600006 India; ²Centre of Bioinformatics, Vision Research Foundation, Sankara Nethralaya, Chennai, India
Email	drjm@snmail.org; *Corresponding author
Article Type	Hypothesis
Date	Received May 07, 2012; Accepted May 10, 2012; Published May 31, 2012
Abstract	Gram-negative bacilli, Enterobacteriaceae and Non-fermentors with resistance to carbapenems and metallo beta-lactams are the major cause of concern in clinical problems in current human healthcare. The most highly emerging dreadful Metallo Beta-lactamses is New Delhi metallo-beta-lactamase (blaNDM-1) which confers resistance to carbapenems; susceptible only to colistin and, less consistently to tigecycline, leading to no therapeutic options. In the present study, we demonstrate the effects of cephalosporins and carbepenems on biofilm producing A. baumanii clinical isolate and also to infer the probable inhibitory binding mode through molecular docking studies. The result of MIC on Biofilm producing A. baumanii and the docking analysis results were found to be concordant. Moreover, we also found cephalosporins and carbepenem groups to interact with 162-166 region of blaNDM-1, which is unique for NDM-1 and also documented to be a potential drug targeting region.
Citation	*Sowmiya et al.* Bioinformation 8(10): 445-452(2012)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.