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Title |
Towards an understating of signal transduction protein interaction networks
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Authors |
Dowluru SVGK Kaladhar1*, Potladurthi Chandra Sai2, Padmanabhuni V Nageswara Rao1, Amajala Krishna chaitanya1, Duddukuri Govinda Rao1, Vadlapudi Varahala Rao3, Erva Rajeswara Reddy2, Sudabattula Vijaya kumar2 & Divyakolu Vinod Kumar1 |
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Affiliation |
1GITAM University, Visakhapatam; 2Madanapalle Institute of Technology and Science, Madanapalle, Chittor; 3Dr Lankapalli Bullayya post graduate college, Visakhapatnam.
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dr.dowluru@gmail.com; *Corresponding author
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Article Type |
Views |
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Date |
Received April 11, 2012; Accepted April 27, 2012; Published May 15, 2012
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Abstract |
Protein network analysis has witnessed a number of advancements in the past for understanding molecular characteristics for important network topologies in biological systems. The signaling pathway regulates cell cycle progression and anti-apoptotic molecules. This pathway is also involved in maintaining cell survival by modulating the activity of apoptosis through RAS, P13K, AKT and BAD activities. The importance of protein-protein interactions to improve usability of the interactome by scoring and ranking interaction data for proteins in signal transduction networks is illustrated using available data and resources.
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Keywords |
Signal transduction, Apoptosis, Angiogenesis
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Citation |
Kaladhar et al.
Bioinformation 8(9): 437-439 (2012) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |