Exploring the role of BCHE in the onset of Diabetes, Obesity and Neurological Disorders

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Title	Exploring the role of BCHE in the onset of Diabetes, Obesity and Neurological Disorders
Authors	Allam Appa Rao¹, Gundlapally Jyothsna², Pulipati Shalini², Amit Kumar²*, Anupam Bhattacharya², Amita Kashyap²
Affiliation	¹Jawaharlal Nehru Technological University, Kakinada,AP, India; ²BioAxis DNA Research Centre Private Limited, Hyderabad, AP, India
Email	amit.kumar@dnares.in; *Corresponding author
Article Type	Hypothesis
Date	Received January 13, 2012; Accepted March 16, 2012; Published March 31, 2012
Abstract	Diabetes, Obesity and Neurological disturbances, most often show co-occurrence. There has been an extensive research in this domain, but the exact mechanism underlying the co-occurrence of the three conditions is still an enigma. The current paper is an approach to establish the role of Butyryl cholinesterase (BCHE) in Diabetes, Obesity and Neurological disorders by performing a comparative analysis with Neuroligin (NLGN2) a protein belonging to the same family. BCHE has its role in glucose regulation, Lipid metabolism and nerve signaling. Emphasis is laid on BCHE’s diverse functions whose impediment affects the above mentioned metabolic pathways. Insilco techniques were employed to analyze the sequence, structural and functional similarities of the two proteins. A point mutation is focused which is common to both BCHE and Neuroligin. The mutation occurs at the homologous position in both the proteins making them deficient. This affects the three metabolic pathways leading to the respective disorders. The work describes the pathway that describes the role of BCHE in the onset of obesity mediated diabetes. The pathway further explains the association between Diabetes, Obesity and neurological disturbances.
Keywords	BCHE, Neuroligin, Diabetes, Obesity, Neurological Abnormalities, Insulin Signaling, Signal Transduction
Citation	*Jyothsna et al.* Bioinformation 8(6): 276-280 (2012)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.