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Title

Exploring the role of BCHE in the onset of Diabetes, Obesity and Neurological Disorders

 

Authors

Allam Appa Rao1, Gundlapally Jyothsna2, Pulipati Shalini2, Amit Kumar2*, Anupam Bhattacharya2, Amita Kashyap2

 

Affiliation

1Jawaharlal Nehru Technological University, Kakinada,AP, India; 2BioAxis DNA Research Centre Private Limited, Hyderabad, AP, India

 

Email

amit.kumar@dnares.in; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received January 13, 2012; Accepted March 16, 2012; Published March 31, 2012

 

Abstract

Diabetes, Obesity and Neurological disturbances, most often show co-occurrence. There has been an extensive research in this domain, but the exact mechanism underlying the co-occurrence of the three conditions is still an enigma. The current paper is an approach to establish the role of Butyryl cholinesterase (BCHE) in Diabetes, Obesity and Neurological disorders by performing a comparative analysis with Neuroligin (NLGN2) a protein belonging to the same family. BCHE has its role in glucose regulation, Lipid metabolism and nerve signaling. Emphasis is laid on BCHE’s diverse functions whose impediment affects the above mentioned metabolic pathways. Insilco techniques were employed to analyze the sequence, structural and functional similarities of the two proteins. A point mutation is focused which is common to both BCHE and Neuroligin. The mutation occurs at the homologous position in both the proteins making them deficient. This affects the three metabolic pathways leading to the respective disorders. The work describes the pathway that describes the role of BCHE in the onset of obesity mediated diabetes. The pathway further explains the association between Diabetes, Obesity and neurological disturbances.

 

Keywords

BCHE, Neuroligin, Diabetes, Obesity, Neurological Abnormalities, Insulin Signaling, Signal Transduction

 

Citation

Jyothsna et al. Bioinformation 8(6): 276-280 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.