Title

Authors

Affiliation

¹Department of Life Sciences, Dibrugarh University, Assam-786004, India; ²Bioinformatics Infrastructure Facility (BIF), Centre for Studies in Biotechnology, Dibrugarh University, Assam-786004, India

Email

ridiphaz@gmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received February 13, 2012; Accepted March 08, 2012; Published March 31, 2012

Diabetes is one of the major life threatening diseases worldwide. It creates major health problems in urban India. Glycogen Synthase Kinase-3 (GSK-3) protein of human is known for phosphorylating and inactivating glycogen synthase which also acts as a negative regulator in the hormonal control of glucose homeostasis. In traditional medicine, Momordica charantia is used as anti-diabetic plant because of its hypoglycemic effect. Hence to block the active site of the GSK-3 protein three anti-diabetic compounds namely, charantin, momordenol & momordicilin were taken from Momordica charantia for docking study and calculation of binding energy. The aim of present investigation is to find the binding energy of three major insulin-like active compounds against glycogen synthase kinase-3 (GSK-3), one of the key proteins involved in carbohydrate metabolism, with the help of molecular docking using ExomeTM Horizon suite. The study recorded minimum binding energy by momordicilin in comparison to the others.

Keywords

Anti-diabetic, Docking, ExomeTM Horizon suite, GSK-3, Momordica charantia

Citation

Hazarika et al. Bioinformation 8(6): 251-254 (2012)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.