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Title

Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis

 

Authors

Ameeruddin Nusrath Unissa1*, Subramanian Sudha2, Nagamiah Selvakumar1, Sameer Hassan3

 

Affiliation

1Department of Mycobacteriology, National Institute for Research in Tuberculosis (NIRT), Indian Council of Medical Research (ICMR), Mayor V.R. Ramanathan Road, Chetput, Chennai - 600 031, Tamil Nadu, India; 2Veterinary College, Chennai - 600 031, Tamil Nadu, India; 3Department of Biomedical Informatics Centre, NIRT, (ICMR), Mayor V.R. Ramanathan Road, Chetput, Chennai - 600 031, Tamil Nadu, India

 

Email

nusrathunissa@gmail.com; *Corresponding author

 

Fax

+91-(044)-2836 2528

 

Article Type

Hypothesis

 

Date

Received July 30, 2011; Accepted August 17, 2011; Published September 28, 2011

 

Abstract

AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.

 

Keywords

M. tuberculosis, modeling, docking, AccD6, INH, INADH, acetyl-CoA.

 

Citation

Unissa et al. Bioinformation 7(3): 107-111 (2011)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.