Title

Authors

Srinivasan Dinesh Kumar^{1, 2}, Kandamaran Krishnamurthy³, Jayapal Manikandan⁴, Praveen N Pakeerappa², Peter Natesan Pushparaj⁵* 

Affiliation

¹Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Ohio-44195, USA; ²Department of Cardiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio-44106, USA; ³Paediatric Intensive Care, Cambridge University NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom; ⁴Deaprtment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD 9, 2 Medical Drive, Singapore 117597; ⁵Institute of Immunity, Infection and Inflammation, College of Medicine, Veterinary and Life Sciences,  Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow, G12 8TA, United Kingdom

Email

peter.n.pushparaj@gmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received April 02, 2011; Accepted April 06, 2011; Published April 22, 2011

Abstract

Recruitment of leukocytes circulating in our blood to the sites of infection or tissue damage is the key phenomenon in the acute inflammatory response(s). Among the leukocytes, neutrophils are primarily recruited into the areas of acute inflammation. When neutrophils interact with activated endothelium of the blood vessels, they become migratory and cross the endothelial layer of the blood vessel wall in a process called as leukocyte extravasation. Identifying and understanding the gene regulation of this extravasation phenomenon is one of the key objective of biomedical research aimed at ameliorating or alleviating the symptoms of various diseases, such as rheumatoid arthritis, asthma, anaphylaxis, atherosclerosis, ulcerative colitis etc., that are exacerbated by inappropriate inflammatory stimuli. Here, we decipher and discuss the key genes implicated in the leukocyte transmigration using the acute inflammation model called as the Dextran Sulphate Sodium (DSS) induced Colitis in mice as a classic paradigm.

Keywords

Leukocytes, Neutrophils Endothelium, Transmigration, Extravasation, Acute Inflammation, Colonic Epithelium, DSS Colitis. 

Citation

Kumar et al. Bioinformation 6(3): 111-114 (2011)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.