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Title |
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A gp63 based vaccine candidate against Visceral Leishmaniasis |
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Authors |
Sukrat Sinha*, Shanthy Sundaram, Anand Prakash Singh, Ashutosh Tripathi |
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Affiliation |
Center for Biotechnology, University of Allahabad, Allahabad, Uttar Pradesh, India-211002 |
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Article Type |
Hypothesis
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Date |
Received November 16, 2010; Accepted November 24, 2010; Published January 22, 2011 |
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Abstract |
Visceral leishmaniasis is a macrophage associated disorder which leads to a profound decrease in the natural immunotherapeutic potential of the infected subjects to combat the disease. The major surface glycoprotein gp63 has been found to be a significant vaccine candidate against visceral leishmaniasis. The current study addresses the levels of similarity and identity in the gp63 obtained from different species of Leishmania viz donovoni, chagasi and infantum linked to the cause of visceral leishmaniasis. The results from BLAST, Phylogram and Cladogram studies indicate significant identity, similarity and conservation of important residues in the protein which lead us to conclude that a common gp63 based vaccine can be used as a therapeutical tool against visceral leishmaniasis caused by different species strains of leishmania. |
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Keywords
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Visceral leishmaniasis (VL), Glycoprotein 63(gp63), Basic Local Alignment Search Tool (BLAST), Cladogram, Phylogram |
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Citation |
Sinha et al. Bioinformation 5(8): 320-325 (2011) |
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Edited by |
Francesco chiappelli
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |